Category: Medicine
Human beings are not the same thing as monkey cells: no, don’t start taking fenofibrate
Audacy (a site for radio stations’ online presence) reports, “Cholesterol drug cuts COVID infection rate by 70%: study”.
Actually, no, that is not what’s reported.
70% reduction in infection would be incredible, so naturally I read the article. I even read the actual journal paper they refer to.
Bonus points for this being an actual, peer-reviewed, published paper in a real journal, Frontiers in Pharmacology Translational Pharmacology. It just does not say anything about infection in humans. It says that the virus failed to infect monkey cells in culture media by up to 70%.
This is a really interesting paper, and I look forward to future work. This could potentially be a useful treatment.
That does not justify the utterly false headline. Audacy reporter Stephanie Raymond apparently either did not read the paper or did not know what Vero cells are and did not bother to look it up. Certainly she did not interview any of the scientists involved. One wonders if she worked off a press release.
Note: in the subject line I said not to start taking fenofibrate. I of course mean, “Unless it’s prescribed by your doctor, for a valid reason.” I am not a medical doctor and I’m not giving medical advice. I’m just saying that you shouldn’t start any prescription med unless it is prescribed by a licensed practitioner.
Kaiser doctor: Cause, Effect, What’s the Difference?
A press release on the Kaiser Permanente web site showcases Doctor Robert Sallis, who conducted a study in which the data on 50,000 KP members diagnosed with COVID-19, finding that people who were less active were 20% more likely to be hospitalized and 30% more likely to die after diagnosis.
Yes, it’s just as nonsensical as you are quite likely thinking.
We know that various comorbidities, such as diabetes, asthma, old age, and kidney disease can result in worse outcomes when someone gets COVID-19. And we also know that these same conditions are associated with lower levels of physical activity.
So Dr. Sallis has found that … sicker people are less active.
But he interprets it as meaning that exercise can save you from dying if you get the disease. That might be true, but the press release comes nowhere near proving it.
Of course, it’s possible the actual paper in the British Journal of Sports Medicine has a more powerful analysis. So I found it.
Umm ….
The activity levels were self-reported. Red flag.
The authors mention confounders. That’s it. They make no effort to account for them, they just vaguely discount them: “There is also the potential issue of residual confounding due to unmeasured confounders or measurement error. However, many studies have demonstrated numerous strong benefits from PA, especially among those who suffer from a variety of chronic diseases.” Yes, but that doesn’t mean that exercise automatically has benefits in every case. It would in principle be possible to do a better analysis, in which you compared people in matched subgroups (groups matched by age and pre-existing conditions, where the only difference between members is level of physical activity). They didn’t bother to do that.
Let me be clear: if I had access to the data I could do that analysis. It isn’t mysterious. They just didn’t.
So … this paper is, let’s say, very far from convincing.
Conspiracy theorizing: killing people again
Wisconsin pharmacist who destroyed more than 500 vaccine doses believes Earth is flat, FBI says.
Pharmacist Steven Brandenberg deliberately ruined over 500 doses of COVID-19 vaccine, by leaving it out of the freezer so that it spoiled.
Why? Because he thought it would be harmful, cause infertility, and that it included some kind of microchip.
Why? Because he believes in conspiracy theories. Notably, he believes that the Earth is flat, and that the sky is fake, a physical dome put in place to prevent people from seeing God. Note that this last theory is not compatible with literally any religion I’ve ever heard of. He isn’t religious–he has fallen down the rabbit hole and is unable to properly reality-check. He’s measuring the value of a proposition, not by how well it comports with reality, but by how cool it would be if it was true.
And … if any of the incorrectly vaccinated or unvaccinated people he deprived of their shots die, he has killed them in the name of nonexistent harms and nonexistent microchips.
For more on conspiracy theorizing:
All science denial is a form of conspiracy theory by Steven Novella.
Terrifyingly transmissible variants?
So, we hear a lot about how the VOC 202012/01 variant (the “British variant”) and 501Y.V2 (the “South African variant”) are more transmissible than the baseline SARS-CoV-2 virus, and there is evidence that this is true.
However, something to keep in mind:
| New Cases of SARS-CoV-2 Infection | UK | South Africa |
|---|---|---|
| Jan 16 | 41,346 | 13,973 |
| Jan 30 | 23,275 | 5,297 |
So, while these new variants are coming to dominate new infections in both nations, both countries have reduced their number of actual infections dramatically. That isn’t an inconsistency–it just indicates that common-sense public health measures like distancing and mask-wearing actually work fine against the new variants. (There are lots of other factors, like the “post-Christmas surge” in cases abating, of course.)
This is what evil looks like
A protest forced the temporary closure of a COVID-19 vaccination site in Los Angeles. They’re literally willing to kill people for the fiction that COVID-19 doesn’t exist.
They’re willing to kill for a lie. I literally can’t think of worse evil. Bigger evil, sure, but not worse.
To quote a post from one of the protestors, “… please refrain from wearing Trump/MAGA attire as we want our statement to resonate with the sheeple. No flags but informational signs only.” Naturally, they had to lie about who they were.
Retail Unmasked
I wrote this to a particular local store. I’m not going to name-and-shame them, so this is an open letter to many retailers:
Hello,
I was in your store this morning.
Several of your staff were wearing their masks either around their necks, or not covering their noses.
This is another way to say, “Not really wearing masks.”
Or, “Not protecting your customers or each other from disease.”
I am deliberately not naming or describing them, because this is not a failure of the hourly employee. It is inevitably and inarguably the responsibility of the management to ensure that the staff follows proper health and safety practices.
If you need assistance, Suffolk County and the State of New York have many resources available to you.
I will note that at least one staffer was apparently walking in to start a shift. You may want to remind them to wear a mask whenever they are in the store, not just when they are on the clock. The same rules that apply to your customers apply to your staff. Masks protect us all, but only if we all wear them.
Let me emphasize that I’m not angry at your staff, or you. I am trying to help protect them, and you, from a potentially deadly disease.
Thank you.
Resurrections in Spain!
According to the Worldometer, 1915 people returned from the dead today (May 25, 2020). Specifically, COVID-19 victims.
I thought this would be the result of a statistical correction, maybe Spain reclassifying a bunch of deaths as being caused by something else, but their News section says nothing about that. My Spanish is very rusty, but their source also doesn’t say such a thing.
I was never that great of a programmer, but surely someone at the Worldometer could have inserted sanity checks for things like the dead rising from the grave. Is Spain threatened by a zombie apocalypse, in addition to the pandemic?
On that same page, they also show that -372 new cases appeared today, and that no one in Spain has recovered from COVID-19 since March 18.
I emailed to let them know about that last anomaly a couple of days ago. No answer so far.
I like the Worldometer’s coronavirus pages and look at them regularly. I have no idea why this slipped through and never got corrected.
Covid-19 and your business: an open letter
In the past few days, I have received emails from hotel chains, supermarkets, convenience stores, travel brands, and a storage locker company explaining how they’re protecting my health from the Covid-19 outbreak. Almost all of them are stamped from the same template:
- We are sanitizing frequently-touched surfaces more often
- If you have reservations, we are giving you flexibility to change them, even if we don’t usually let you cancel without penalty
- We’re following applicable recommendations from WHO and the CDC
Only one, 7-Eleven, has mentioned a critical one: asking sick people to not come in, and saying that they’re directing any employee to stay home if feeling ill. That last is obviously key, though. Here’s the thing: they don’t mention “And we’re giving them sick pay.”
People who work in restaurants and convenience stores are often part-timers with no benefits, and in particular no paid sick days. Telling a person who needs her pay from the night shift to feed her kids, “Just stay home if you run a fever,” is like saying “Just let your family starve if you run a fever.” They won’t and they can’t.
So: how seriously do you really take this outbreak? Are you ready to pay your staff to stay home when sick? Because if not … then people will inevitably die.
No, I don’t think the Thais have cured the Wuhan virus
Did you see that Thai doctors have cured the Novel Coronavirus?
https://www.ibtimes.co.in/cocktail-flu- … and-812699
Don’t hold your breath. They claim to have used anti-HIV drugs. Those are almost all antiretrovirals. Coronavirii are not retroviruses. It seems very unlikely meds that work by inhibiting the enzyme reverse transcriptase would affect members of the Coronaviridae, since the RNA of a coronavirus is not reverse-transcribed into DNA.
Oseltamivir (trade name Tamiflu), their third drug, is specific to influenza and again would not be expected to work against a totally different type of virus. I actually found a Chinese study that tested it against the SARS virus (close relative of 2019-nCoV) and found no activity.
https://wwwnc.cdc.gov/eid/article/10/4/pdfs/03-0458.pdf
The whole media brouhaha is based on … one patient.
I can’t rule it out. I can and do doubt it a lot.
Parents torture child, nearly kill him. No mention of charges.
Warning: I am very, very angry.
In Oregon (in 2017), a child was diagnosed with tetanus. It was the first case in that state in over 3 decades.
The parent withheld the DTAP vaccine (which prevents Diphtheria, Tetanus, and Pertussis) despite medical recommendations. Their son got a cut while playing, they treated it themselves (with home suturing!) and didn’t seek medical attention until he developed the classic symptom of tetanus — involuntary muscle contractions. It reached the point where he could not breathe without both drugs and mechanical assistance. With devoted care from many practitioners over a period of two months, the team in Oregon managed to save him from his parents.
As part of treatment he got one dose of DTAP. Five are suggested for full protection. Even after he got a deadly disease that came very close to killing him and meant months of hospitalization and rehab, the parents said that they would refuse to give him the other four doses.
In a just world, they would be sentenced to daily injections of strychnine for two months. Enough to put their own muscles in spasm to the point that they needed mechanical help to breathe. In our world, there seems to be no mention of even a Child Protective Services investigation. I’m sort of glad I have no way to know the names of these hideous monsters, because I would feel some obligation to drive to Oregon and scream at them.
No, that is not hyperbole. They badwording tortured a helpless child. Monsters.
Reasonably Literate 